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The Top Causes of Death in the United States, Ranked

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The Top Causes of Death in the United States

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Key Takeaways

  • The 10 leading causes of death account for 71% of all deaths occurring in the United States.
  • Accidents are the #3 cause of death in the U.S. (222,698 deaths, 7.2%).
  • Unintentional injuries rank #3 for men (9.2% of deaths), but only #6 for women (5.0%).

This infographic shows the leading causes of death in the U.S., based on recent data from the Centers for Disease Control and Prevention (CDC).

Heart Disease and Cancer Dominate

Heart disease was responsible for 680,981 deaths (22% of the total), making it the leading cause of death. Cancer followed closely with 613,352 deaths (nearly 20%).

Accidents Rank Third

Unintentional injuries, often tied to traffic accidents, falls, or overdoses, caused 222,698 deaths. This makes them the third-leading cause of death overall, and a major outlier compared to other chronic or age-related conditions. Notably, accidents impact men more heavily, ranking third for them, while they fall to sixth among women.

Rank Cause of Death Deaths % of Total
1 Heart diseases 680,981 22.0%
2 Cancer 613,352 19.8%
3 Accidental injuries 222,698 7.2%
4 Cerebrovascular diseases 162,639 5.3%
5 Chronic lower respiratory diseases 145,357 4.7%
6 Alzheimer disease 114,034 3.7%
7 Diabetes 95,190 3.1%
8 Kidney diseases 55,253 1.8%
9 Chronic liver disease and cirrhosis 52,222 1.7%
10 COVID-19 49,932 1.6%
- Other Causes 899,306 29.1%
- All causes (total) 3,090,964 100.0%

Aging-Related Diseases on the Rise

Alzheimer’s disease ranked sixth with 114,034 deaths, reflecting the country’s aging population. Meanwhile, other chronic conditions such as diabetes (95,190 deaths) and kidney disease (55,253 deaths) also remain significant. Although COVID-19 caused nearly 50,000 deaths in 2023, it now ranks tenth, far below its peak impact earlier in the pandemic.

Chronic Conditions Among Women

For women, stroke and Alzheimer’s disease rank higher than among men, reflecting longevity differences and aging-related health risks. Stroke is the third-leading cause of death for women at 6.2%, compared to fourth for men at 4.4%. Alzheimer’s also ranks higher among women (5.3%) than men (2.2%), consistent with the fact that women live longer on average.

Rank Female – Cause of Death %
1 Heart disease 20.7
2 Cancer 19.8
3 Stroke 6.2
4 Alzheimer disease 5.3
5 Chronic lower respiratory diseases 5.3
6 Unintentional injuries 5
7 Diabetes 2.7
8 Kidney disease 1.8
9 COVID-19 1.6
10 Hypertension 1.5
Other 30

Mental Health and Other Conditions

Suicide appears in the top 10 for men, making up 2.4% of all male deaths, but it does not appear on the female list. Conversely, hypertension ranks tenth among women (1.5%), while it does not appear in the male rankings.

Rank Male – Cause of Death %
1 Heart disease 23.3
2 Cancer 19.9
3 Unintentional injuries 9.2
4 Stroke 4.4
5 Chronic lower respiratory diseases 4.2
6 Diabetes 3.4
7 Suicide 2.4
8 Alzheimer disease 2.2
9 Chronic liver disease and cirrhosis 2
10 Kidney disease 1.8
Other 27.3

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